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Drug Sensitivity and
Resistance Testing (DSRT)

Reliably transfer samples and reagents from any well to any well

HOME | APPLICATIONS | DSRT

Improve Decisions for Precision Cancer Therapy

Test combinations of drugs, antibodies, and siRNA molecules in low volumes to identify impacts to cell functioning or toxicity. Echo liquid handlers reliably transfer samples and reagents from any well to any well to improve assay sensitivity and reproducibility.

Echo 525 Liquid Handler Echo® 555 LIQUID HANDLER

Accelerate Precision Medicine with Efficient Drug Sensitivity and Resistance Testing

Recently identified associations between variants of cancer genes and drug resistance have increased the value for comprehensive drug sensitivity screening in combination with molecular profiling of cancer cells. In cancer research, the information from drug sensitivity screening is often used to improve the precision of therapy offered to patients. This can involve treatment with re-purposed therapeutics, novel therapeutics or combinations of therapeutics. Comparison of drug sensitivity information along with the molecular profile of certain cancer cells can enable the identification of underlying genetic links to drug resistance.


As these programs are scaled up, operational costs to prepare samples and perform screening can become rate limiting, delaying treatment decisions. Researchers have found that miniaturization from the use of acoustic liquid handling instead of traditional methods has increased the overall efficiency of drug sensitivity screening by lowering costs while improving data quality and throughput. Echo Dose-Response software enables direct dilution and normalization of simple or complex concentration curves from a range of sample types. With direct dilution, Echo Liquid Handlers produce dose-response assays without the risk of carryover or contamination common to tip-based serial dilution methods.

Key Benefits

  • Consistently superior results through precise touchless liquid handling
  • Support for a range of assay formats from 96-, 384- and 1536-well microplates to chips or arrays
  • Modular workstations that scale easily to include incubation, detection and bulk reagent dispensing
  • Commercially available Dharmacon or QIAGEN libraries in Labcyte source plates enable miniaturized siRNA screens without manual intervention
VIDEO
Precision Medicine Research at the Institute for Molecular Medicine Finland
Krister Wennerberg and Labcyte
Krister Wennerberg, Ph.D.    |   FIMM-EMBL Group Leader
Dr. Krister Wennerberg describes his experience of using the Echo liquid handler to drive precision medicine research at FIMM.
WEBINAR
Accelerating Precision Medicine with Efficient Drug Sensitivity Screening
Krister Wennerberg and Labcyte
Krister Wennerberg, Ph.D.    |   FIMM-EMBL Group Leader
Brad Nelson    |   Labcyte Inc.
For Research Use Only Not for use in Diagnostics