for pharmacokinetic (PK) and pharmacodynamic (PD) studies
High precision, low volume fluid transfers by the Echo Liquid Handler make it possible for researchers to perform serial sampling for pharmacokinetic (PK) and pharmacodynamic (PD) studies — dramatically reducing study costs and animal use while increasing data quality.
In a typical mouse PK study, you can up to save 9X the number of mice* — helping your lab better address the 3 R’s and animal welfare.
Composite PK Studies
Serial PK Studies
In addition to the highly accurate and precise transfers, non-contact acoustic dispensing performed by Echo Liquid Handlers eliminates the potential for compound loss on tips making the transition to microsampling easier. Increased compound potency enables the use of miniaturized reactions, reducing the volume of plasma needed per PK study and allowing for the use of microsampling.
In a Medimmune study**, the use of the Echo Liquid Handler in peptide PK assays showed an increase of 88% data collected per animal. This gain was attributed to the elimination of peptides absorbance to tips, requiring the use of less sample and directly resulting in the reduction in animal usage.
|Technology Used to Perform Study||Volume of Serum Required / Time Point||# of Time Points Possible / Animal|
|Tip-based liquid handler||40 µL||3|
|Echo® Acoustic Liquid Handler||5 µL||24|
|Technology Used to Perform Study||Tip-based liquid handler|
|Volume of Serum Required / Time Point||40 µL|
|# of Time Points Possible / Animal||3|
|Technology Used to Perform Study||Echo® Acoustic Liquid Handler|
|Volume of Serum Required / Time Point||5 µL|
|# of Time Points Possible / Animal||24|
* Joyce, A.; M. Wang; R. Lawrence-Henderson et al. (2014) One Mouse, One Pharmacokinetic Profile: Quantitiave Whole Blood Sampling Serial Sampling for Biotherapeutics. Pharm Res. DO1 10.007/s1 1095-013-1286-y.
** Naylor, J.; A. Rossi; and D. Hornigold. (2016) Acoustic Dispensing Preserves the Potency of Therapeutic Peptides throughout the Entire Drug Discovery Workflow. JALA. 21(1), 90-96.