SLAS has published the 2017 SLAS Technology Ten, in which the editors highlight their picks for the best work published in their journal throughout the previous year. Labcyte is proud to be recognized in the first two entries, which describe how our customers used the Echo® Liquid Handlers to enable technological advances that make significant contributions to life sciences and biomedical research and applications. Here are abbreviated summaries of the papers, and links to download them for free...
Click the image on the right to view paper.
Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing
by Evgeny Kulesskiy, Jani Saarela, Laura Turunen, and Krister Wennerberg of the Institute for Molecular Medicine Finland (FIMM), University of Helsinki, and the Helsinki University Hospital
The authors describe how Labcyte technology is enabling drug sensitivity and resistance testing in their cancer individualized systems medicine program. The drug sensitivity information is used with molecular profiling to establish hypotheses on individual cancer-selective targeting drug combinations and their predictive biomarkers, which can be explored in the clinic. The team is using the Echo liquid handlers to generate consistent assay-ready plates, flexibly prepare drug combination testing plates, dispense reagents and cells to the assay plates, and perform ultra-miniaturized follow-up assays on the cells.
Smart DNA Fabrication Using Sound Waves: Applying Acoustic Dispensing Technologies to Synthetic Biology
by Paulina Kanigowska, Yue Shen, Yijing Zheng, Susan Rosser, and Yizhi Cai of the University of Edinburgh and BGI-Shenzhen
The authors describe the application of acoustic droplet ejection technology for DNA synthesis and assembly at the nanoliter scale using a Labcyte Echo 550 acoustic dispenser. The scientists were able to successfully downscale PCRs and the popular one-pot DNA assembly methods, Golden Gate and Gibson assemblies, from the microliter to the nanoliter scale with high assembly efficiency, which effectively cut the reagent cost by 20- to 100-fold.
As the editor notes, this year’s highlighted articles show how scientists “continue to push the envelope of what is possible with automation, integrating new functions into high-throughput sample preparation and screening to further drive efficiencies in research.” Our congratulations go out to everyone whose work was recognized in the special feature.