We’re pleased to report a new application for the Echo Liquid Handler, with plenty of resources available if you’re interested in learning more. Serial microsampling allows scientists to use fewer animals in studies and reduce costs without compromising data quality. This is particularly useful for scientists conducting pharmacokinetics (PK) and pharmacodynamics (PD) research.
Because of its highly precise, low-volume fluid transfers powered by acoustic energy, the Echo Liquid Handlers make it possible to generate useful results from just 1 µL of plasma, compared to 50 µL required for traditional liquid handling solutions. For a typical PK study, this approach allows scientists to use one-ninth the number of mice, simultaneously improving data quality and animal welfare. It also decreases the problematic animal-to-animal variability by allowing repeated sampling of the same animal during testing and makes it possible to use the same animals for PK and PD studies for optimal correlation between drug dose and effect.
For more information, check out our applications page, this poster on microsampling in a study of mini-pigs, or this Medimmune study showing an 88% increase of data collected per animal in peptide PK assays with the Echo Liquid Handler.
Here at Labcyte, we support the three R’s of animal welfare (as laid out by The National Centre for the Replacement, Refinement, and Reduction of Animals in Research): Replace, Refine, Reduce. We’re proud to deliver technology that dramatically reduces the need for animals in research, reduces stress for each test animal, and minimizes animal mortality.