Home

Applications

APPLICATIONS OVERVIEW
DRUG DISCOVERY
ADME-Tox
Biochemical Assays
Cell-based Assays
HTS and Secondary Screening
Microsampling
Protein Crystallography
RNAi
Sample Management
CANCER RESEARCH
Personalized Medicine
Functional Screening / DSRT
RNAi
Sequencing
Single-cell Genomics
GENOMIC RESEARCH
Gene Expression
Genotyping
Microbiome
qPCR
Sequencing
Single-cell Genomics
Synthetic Biology

Products

LIQUID HANDLING
LIQUID HANDLERS OVERVIEW
Echo® 525 Liquid Handler
Echo® 555 Liquid Handler
Echo® 550 Liquid Handler
Echo® 520 Liquid Handler
AUTOMATION
AUTOMATION OVERVIEW
Access™ Laboratory Workstation
Tempo™ Automation Control Software
SOFTWARE APPLICATIONS
SOFTWARE OVERVIEW
Echo® Array Maker
Echo® Cherry Pick
Echo® Combination Screen
Echo® Compliance Manager
Echo® Dose-Response
Echo® Plate Audit
Echo® Plate Reformat
CONSUMABLES
CONSUMABLES OVERVIEW
Echo® Qualified Microplates
Labcyte® Assay Microplates
MicroClime® Environmental Lid
Echo® Qualified Reservoir

Technology

Echo® Acoustic Liquid Handling
Dynamic Fluid Analysis™
Acoustic Mass Spectrometry
Direct Dilution

News / Events

Labcyte BLOG
Upcoming Events
Press Releases
Labcyte in the News
Labcyte Community

Resources

JALA Special Issue
Publications
Articles and Other Media
Application Notes
Posters
Webinars
Videos
Customer Profiles
Core Labs

Support

Brochures
Web Documentation*
User Guides*
Quick Start Guides*
Specification Sheets
Site Prep Guides
Service and Maintenance
Request Information

Company

About Us
Echo® Acoustic Technology
Leadership Team
Meet Labcyte
Careers
Contact and Location
Privacy Policy

National Cancer Institute Awards Labcyte $1 Million for Novel High-Throughput Cancer Biomarker Detection

Labcyte Inc., the acoustic dispensing company, has been awarded $1 million to create an innovative process to detect cancer-related proteins in samples, with initial work in breast cancer detection. The unsurpassed precision and accuracy of Labcyte acoustic liquid handling enables biomarker detection by measuring multiple proteins with a MALDI mass spectrometer. Recent work with the Canary Center at Stanford, also supported by the National Cancer Institute, showed the ability to achieve the sensitivity required for quantifying very small amounts of proteins associated with ovarian cancer. Measuring the amount of multiple proteins, and at lower cost, is an essential step in developing new diagnostic tools for disease treatment and monitoring.

November 20, 2013

Sunnyvale, CA

SUNNYVALE, Calif.November 20, 2013 Labcyte Inc., the acoustic dispensing company, has been awarded $1 million to create an innovative process to detect cancer-related proteins in samples, with initial work in breast cancer detection.  The unsurpassed precision and accuracy of Labcyte acoustic liquid handling enables biomarker detection by measuring multiple proteins with a MALDI mass spectrometer.  Recent work with the Canary Center at Stanford, also supported by the National Cancer Institute, showed the ability to achieve the sensitivity required for quantifying very small amounts of proteins associated with ovarian cancer. Measuring the amount of multiple proteins, and at lower cost, is an essential step in developing new diagnostic tools for disease treatment and monitoring.

This cutting-edge process encompasses stable standards and capture of biomarkers with antibodies and expects to achieve greater throughput than traditional liquid chromatography-mass spectrometric approaches.  The utility of this technique will be tested by simultaneously analyzing 16 different biomarkers, run in quadruplicate, to simulate the analysis of 64 unique biomarkers.  The process has the potential to expand to a greater number of biomarkers as well.  It may enable significant advances in diagnostics and discovery.

"I am particularly enthusiastic about participating with Labcyte on the further development of their protein multiplexed biomarker detection platform,” said Dr. Mark Stolowitz, Director of the Proteomics Core Facility at the Canary Center at Stanford for Cancer Early Detection.  “This novel immunoaffinity mass spectrometry based approach exploits MALDI-TOF-MS for detection of proteotypic peptides. The platform affords sensitivity comparable to that of triple-quad mass spectrometers while providing significantly greater throughput and better precision than that obtainable from LC-MS/MS based approaches. Over the next few years, the Labcyte platform should provide the high throughput biomarker verification/validation solution that researchers have sought in conjunction with the emergence of clinical proteomics."

In addition to working with the Canary Center, the Labcyte project includes collaboration with the Fred Hutchinson Cancer Research Center in Seattle, Washington.

“We are excited to work with Dr. Stolowitz to explore the potential advantages of the Labcyte platform to increase the throughput beyond that of existing immuno-MRM assays,” said Dr. Amanda Paulovich, an associate member of the Clinical Research Division at the Fred Hutchinson Cancer Research Center.

“Better identification and quantification of multiple biomarkers are critical tools for researchers and clinicians to fight cancer and a wide variety of other diseases,” said Rich Ellson, CTO of Labcyte.  “The unique, revolutionary aspects of acoustic dispensing are essential for the process. We are eager to work with Dr. Stolowitz and Dr. Paulovich, as this could become fundamental for biomarker development.”

This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institute of Health and Human Services under Contract No. HHSN261201300089C.

About Labcyte Inc.
Labcyte, a global biotechnology tools company headquartered in Sunnyvale, California, is revolutionizing liquid handling. Echo liquid handling systems use sound to precisely transfer liquids without contact, eliminating the use of pipettes. Labcyte instruments are used worldwide throughout the pharmaceutical industry, as well as by biotechnology firms, contract research organizations, and academic institutions. Our customers work across a wide spectrum of scientific research, including drug discovery, genomics, proteomics, diagnostics, personalized medicine, and imaging mass spectrometry. Labcyte has 53 U.S. patents and others internationally. For more information, visit www.labcyte.com.

About the Canary Center
The Canary Center at Stanford is a world-class facility dedicated to cancer early detection research programs. The mission of the center is to foster research leading to the development of blood tests and molecular imaging approaches to detect and localize early cancers. The center is the first in the world to integrate research on both in vivo and in vitro diagnostics to deliver these tests, by housing state-of-the-art core facilities and collaborative research programs in molecular imaging, proteomics, chemistry, and bioinformatics. These initiatives have extensive links to the Cancer Center at Stanford, forming a direct pipeline for the translation of early cancer detection research into clinical trials and practice. The Center was established through an alliance between the Canary Foundation, the Department of Radiology, and the School of Medicine. canarycenter.stanford.edu

About the Fred Hutchinson Cancer Research Center
At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Private contributions are essential for enabling Fred Hutch scientists to explore novel research opportunities that lead to important medical breakthroughs. For more information visit www.fredhutch.org or follow Fred Hutch on Facebook, Twitter or YouTube.
 




MAIN CONTACT
LABCYTE INC.
170 Rose Orchard Way
San Jose, California 95134
USA
Tel:
+1 408 747-2000
Toll-free:
+1 877 742-6548
Sales:
+1 877 742-6548, option 1
Fax:
+1 408 747-2010
Contact:
REQUEST INFO

PRESS CONTACT
Nicole Litchfield
Bioscribe, Inc.
Tel:
+1 415 793-6468
Email:
nicole@bioscribe.com
TOP