Echo 550 Liquid Handler | Labcyte Inc.

Echo® 550
LIQUID HANDLER

for medium throughput screening and large genomics projects

  • Most diverse application range of the Echo Liquid Handler family
  • Impact all phases of drug discovery process
  • Save money, increase data quality in large genomics projects
HOME | PRODUCTS | Echo® 555 Liquid Handler

Impacting Science

Acoustic liquid handling is changing how researchers are doing science. The precise nL transfer volumes, the any well any well transfer capability, and flexible applications software of the Echo 550 Liquid Handler enables researchers to set up experiments not previously doable with traditional liquid handling.

MOVE LIQUIDS with SOUND

Echo Liquid Handling Technology

See how liquid is transferred from any well to any well with the Echo liquid handling technology

Acoustic liquid handling is changing how researchers are doing science. The precise nL transfer volumes, the any well any well transfer capability, and flexible applications software of the Echo 550 Liquid Handler enables researchers to set up experiments not previously doable with traditional liquid handling.

WIDE RANGE of APPLICATIONS

With a combination of high transfer speeds and diverse fluid transfer capabilities, the Echo 550 Liquid Handler supports a wide range of applications in Drug Discovery and Basic Research.


GENOMICS


DRUG DISCOVERY


    Key Benefits

  • Improved information about compound integrity and improved transfer quality through measurement of DMSO hydration level
  • Elimination of sample and compound loss, cross-contamination, carryover or leachates through the elimination of tips
  • Accurate, precise movement of nanoliter-scale quantities, enabling assay miniaturization, further reducing costs
  • Better results through direct dilution of compounds, an improvement over serial dilution methods
  • Greatly simplified assay development and dilution processes through the flexibility to transfer any volume of liquid from any well to any other well
VIDEO
The Echo® Liquid Handling Technology
Echo Liquid Handling Technology
Echo Acoustic Liquid Handling    |   by Labcyte Inc.
The Echo Liquid Handler revolutionizes liquid handling with acoustic energy. Sound waves eject precisely sized droplets from a source onto a microplate, slide or other surface suspended above the source.

Decrease Cost, Maintain Data Quality



The high performance fluid transfer of Echo 550 Liquid Handler delivers comparable transfer efficiency, knock-down, and cell morphology reactions to traditional liquid handlers with less use of sample and reagent.



FIGURE: Fluorescence image reveals KYSE cells successfully transfected with siGLO(GE Healthcare) (pink),transferred using the Echo Liquid Handler.



Inclusion intensities of esphogeal cancer cells transfected using the Echo Liquid Handler vs. manual transfer. Error bars indicate standard deviations.

Transition Into High-throughput Formats

High assay performance at miniaturized volumes enables the researchers to move quantitative assays into higher density formats. Assays such as time-dependent inhibition assays perform comparably to traditional volumes with less reagent, compound, and the elimination of workflow steps.



FIGURE: Time-dependent CYP1A2 inhibition profiling with two inhibitors

    EC50 (nM)     EC50 (nM)
  - NADPH   40.27   - NADPH   14273
  + NADPH   7.96   + NADPH   150.3
  δ IC50   5   δ IC50   95



PRODUCT HIGHLIGHTS

The Echo 555 Liquid Handler has the speed and flexibility required for a screening lab. With rapid, highly precise nL volume transfers, Echo 555 Liquid Handler can process over 650* compound and over 500* reagent plates per day. Tasks like plate reformatting, hit picking, daughter plate creation, and adding samples and reagents for screening assays are made easy with the Echo 555 Liquid Handler.

*Based on 100nL volume transfers

  • No user calibration required
  • Minimum transfer increment: 25 nL
  • Source microplates: 384-well
  • Destination: most SBS-format microplates
  • Barcode reader options: short side and/or long side