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Echo 555 Liquid Handler | Labcyte Inc.

Echo® 555
LIQUID HANDLER

for high throughput screening

  • Fastest transfer speeds of the Echo Liquid Handler family
  • Broad application range
  • Fast, accurate, and precise liquid transfers in nanoliter volumes
HOME | PRODUCTS | Echo® 555 Liquid Handler

Addressing the Demands of
High-throughput Screening Labs

The Echo 555 Liquid Handler has the speed and flexibility required for a screening lab. With rapid, highly precise nL volume transfers, Echo 555 Liquid Handler can process over 650* compound and over 500* reagent plates per day. Tasks like plate reformatting, hit picking, daughter plate creation, and adding samples and reagents for screening assays are made easy with the Echo 555 Liquid Handler.

*Based on 100 nL volume transfers

MOVE LIQUIDS with SOUND

Echo Liquid Handling Technology

See how liquid is transferred from any well to any well with the Echo liquid handling technology

The Echo 555 Liquid Handler has the speed and flexibility required for a screening lab. With rapid, highly precise nL volume transfers, Echo 555 Liquid Handler can process over 650* compound and over 500* reagent plates per day. Tasks like plate reformatting, hit picking, daughter plate creation, and adding samples and reagents for screening assays are made easy with the Echo 555 Liquid Handler.

*Based on 100nL volume transfers

BROAD RANGE of APPLICATIONS

Going beyond DMSO used in high throughput screening, the Echo 555 system supports the transfer of a broad range of aqueous solutions to support high throughput screening laboratories.


    Key Benefits

  • Tipless transfer, resulting in dramatic cost savings
  • Improved information about sample integrity and improved transfer quality through measurement of DMSO hydration level
  • Elimination of compound loss, cross-contamination, carryover or leachates through non-contact transfer
  • Extend compound library life through miniaturization of assays
  • Greatly simplified assay development and dilution processes through the flexibility to transfer any volume of liquid from any well to any other well
VIDEO
The Echo® Liquid Handling Technology
Echo Liquid Handling Technology
Echo Acoustic Liquid Handling    |   by Labcyte Inc.
The Echo Liquid Handler revolutionizes liquid handling with acoustic energy. Sound waves eject precisely sized droplets from a source onto a microplate, slide or other surface suspended above the source.

Impacting Therapeutic Discovery

Tipless, non-contact, acoustic fluid transfer of the Echo 555 Liquid Handler eliminates the potential for samples or compounds to adhere to tips. This helps to improve data quality, increasing the potential to find new therapeutics.

32% More Active Compounds Found



In a screen of 975 compounds, Bristol-Myers Squibb found 108 more hits when using the Echo Liquid Handler1.



1 Spicer T., Fitzgerald Y., Burford N., Matson S., Chatterjee M., Gilchrist M.,Myslik J., O'Connell J.
Pharmacological evaluation of different compound dilution and transfer paradigms on an enzyme assay in low volume 384-well format. Poster presented at Drug Discovery Technology, August 2005, Boston, MA.

Save Compounds and Money – Miniaturized Cell-based Biochemical Assay

Utilize the Echo 555 Liquid Handler to set up 384-well cell-based and biochemical assays or transition into 1536-well formats with no loss of performance. The nL volume transfers of the Echo 555 systems enable direct dilution of concentrated compounds – eliminating workflow steps and keeping the final concentration of DMSO low in the final assay. Data accuracy is further improved through the elimination of compound loss on tips.



FIGURE: Stimulation curves and EC50 values for isoproterenol, salbutamol, and salmeterol in 384-well (left) and 1536-well (right), LV white microplate. Incubation time of 60 minutes. BMG Labtech PHERAstar FS.


    EC50     EC50
  Isoproterenol   0.8 nM   Isoproterenol   0.8 nM
  Salbutamol   11 nM   Salbutamol   27 nM
  Salmeterol   3.2 nM   Salmeterol   0.2 nM
  Z’ Factor   0.72   Z’ Factor   0.89



Making High-throughput Combination Screening a Reality

Drug combination screening using the Echo 555 Liquid Handler has revolutionized the approach to the assessment of synergistic effects of drug combinations on disease. The any-well-to-any-well fluid transfer and the Echo Combination Screening application software makes high throughput, 2-way and 3-way dose response matrix studies a reality.



PRODUCT HIGHLIGHTS

The Echo 555 Liquid Handler has the speed and flexibility required for a screening lab. With rapid, highly precise nL volume transfers, Echo 555 Liquid Handler can process over 650* compound and over 500* reagent plates per day. Tasks like plate reformatting, hit picking, daughter plate creation, and adding samples and reagents for screening assays are made easy with the Echo 555 Liquid Handler.

*Based on 100nL volume transfers

  • No user calibration required
  • Minimum transfer increment: 25 nL
  • Source microplates: 384-well
  • Destination: most SBS-format microplates
  • Barcode reader options: short side and/or long side