Dispense a broad range of sparse matrix crystallography fluids in low-volume
Dynamic Fluid Analysis Allows Screening, Microcrystal Transfer and Grid Screen Creation
Structural biologists have long been forced to deal with the limitations of traditional liquid handlers when planning crystallization experiments. The Echo Liquid Handler eliminates these limitations by dispensing a broad range of sparse matrix crystallography fluids in low-volume increments of 2.5 nL.
Echo 555 LIQUID HANDLER
Technology that Supports Precise Transfers
Using Dynamic Fluid Analysis, the Echo Liquid Handler acoustically interrogates each well and automatically adjusts power requirements—helping ensure precise transfer of hundreds of crystallography screens with one self-adjusting fluid type. Labcyte customers use the Echo Liquid Handler to transfer microcrystals and additive screens—and to generate grid screen conditions on the fly. The Echo 555 and 550 models can also transfer small volumes of compound. This simplifies co-crystallization processes at low volumes.
Accurate and precise transfer of a wide range of liquids
Non-contact transfer of crystallization screens, additives and proteins
Drop-on-drop performance at final assay volumes of 50 nL or less
Microcrystal transfer to enable low-volume optimization trials
Simplification of grid screen formulation through the on-the-fly creation of screens from concentrated stock reagents
Minimization of DMSO interference while investigating small molecule binding
Advances in Acoustic Protein Crystallography Screening Using the Echo Liquid Handler