Just how personalized is today’s personalized medicine? Krister Wennerberg, Labcyte customer and collaborator at Finland’s Institute for Molecular Medicine (FIMM) discussed the topic on Mendelspod, highlighting a novel way that his institute is combining different types of studies to make treatment more individualized.
FIMM’s “individualized systems medicine” combines traditional molecular profiling with functional profiling and clinical information in order to get a better picture of the patient’s disease, he explains. The group first tested this approach, which involves taking primary cells from patients and testing their cells ex vivo with a variety of drugs to see what kills the cancer, in patients with late-stage leukemia. The idea is to have a quick way of predicting what a patient might respond to...
As functional screening programs scale up, operational costs can become problematic, potentially delaying the more widespread implementation of the technique. Researchers have found that miniaturization from the use of acoustic liquid handling instead of traditional methods has increased the overall efficiency of functional screening by lowering costs while improving data quality and throughput.
Echo Dose-Response software enables direct dilution
and normalization of simple or complex concentration curves from a range of sample types. With direct dilution, Echo Liquid Handlers produce dose-response assays without the risk of carryover or contamination common to tip-based serial dilution methods.
Allan Jordan 博士|英国癌症研究院曼彻斯特研究所 [with SelectScience]
Allan Jordan博士（英国癌症研究院曼彻斯特研究所药物研发小组化学领域负责人）描述了其研究所是如何使用Labcyte Echo® 550的声波液体分配来帮助加快化合物筛选的。