APPLICATION NOTES

Utilization of the Labcyte MicroClime® Environmental Lid to Reduce...

John Lesnick, Linda Orren, Noёl Ruppert

ABSTRACT

In this study, we demonstrate the benefit of utilizing the Labcyte MicroClime Environmental Lid to reduce edge effects in a functional cell-based assay by measuri...

D105
2018
PDF | 1.31 MB
Miniaturized 16S rRNA Amplicon Sequencing with the Labcyte Echo® 52...

Jefferson Lai and John Lesnick

ABSTRACT

Our understanding of the microbial communities in human health, metagenomics, and metataxonomics has been growing rapidly in recent years and is being increasingl...

G123
2017
PDF | 3.99 MB
Echo-Enhanced SMART-Seq® v4 for RNA Sequencing

Jefferson Lai, Anna Lehto, John Lesnick and Carl Jarman

ABSTRACT

As the cost of sequencing has continued to decline by orders of magnitude in the past ten years, scientists are enabled to ask deeper and more complex questions a...

G122
2017
PDF | 3.05 MB
A Method to Streamline and Miniaturize Nextera™ Library Preparation...

John Lesnick

ABSTRACT

The ongoing evolution of next-generation sequencing (NGS) technologies has reduced sequencing costs by orders of magnitude and significantly increased throughput....

G118
2017
PDF | 750.91 KB
High-throughput Miniaturization of Cytochrome P450 Time-dependent I...

Jing Wang

ABSTRACT

Early assessment of the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) properties of drug candidates has become a critical part of modern dr...

D101
2017
PDF | 265.90 KB
Miniaturization of Cytochrome P450 Time-dependent Inhibition Screen...

Jing Wang

ABSTRACT

Early assessment of the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) properties of drug candidates has become a critical part of modern dr...

D102
2017
PDF | 263.68 KB
Miniaturization of Multiple Displacement Amplification (MDA) of Gen...

Labcyte

ABSTRACT

Advances in whole-genome amplification have enabled sequencing of DNA and RNA from a single cell, or what is commonly called Single-cell Genomics (SCG). SCG has b...

G106
2017
PDF | 281.42 KB
The reliability of assay-ready plates for cell-based screening enab...

Sheraz Gul and Markus Wolf

ABSTRACT

In a collaboration between the Fraunhofer Institute for Molecular Biology and Applied Ecology (Hamburg, Germany),
and the National University of Ireland (NU...

CUSTOMER APP NOTE
2017
PDF | 1.01 MB
Preparation of Mouse Plasma Microsamples for LC-MS/MS Analysis Usin...

Randy Dyer

ABSTRACT

Serial microsampling of animals reduces the overall number of animals sampled and euthanized for toxicology studies. Traditional composite studies in mice can req...

D111
2017
PDF | 287.25 KB
Effective Miniaturization of Illumina Nextera XT Library Prep for M...

Jefferson Lai, John Lesnick, Noël Ruppert

ABSTRACT

The cost of sequencing per nucleotide has been declining by orders of magnitude over the past ten years; however library preparation of samples for next-generatio...

G121
2017
PDF | 965.62 KB
High-Precision Cell Dispensing with the Labcyte Echo® Liquid Handler

John Lesnick, Aurore Lejeune-Dodge, Noël Ruppert, Carl Jarman

ABSTRACT

In this technical note, we demonstrate the utility of the Labcyte Echo Liquid Handler to accurately dispense a variety of cell lines to ensure uniformity and viab...

D107
2016
PDF | 1.26 MB
Miniaturized PIK3CA Mutational Analysis Utilizing the Labcyte Echo®...

John Lesnick, Linda Orren, Noël Ruppert

ABSTRACT

By combining the acoustic liquid transfer of the Labcyte Echo Liquid Handler with real-time PCR mutation analysis, we have demonstrated a highly efficient, low-co...

G115
2016
PDF | 1.54 MB