APPLICATION NOTES

Utilization of the Labcyte MicroClime® Environmental Lid to Reduce...DOWNLOAD

D105

Utilization of the Labcyte MicroClime® Environmental Lid to Reduce...

John Lesnick, Linda Orren, Noёl Ruppert

ABSTRACT

In this study, we demonstrate the benefit of utilizing the Labcyte MicroClime Environmental Lid to reduce edge effects in a functional cell-based assay by measuri...

2018
PDF | 1.31 MB
Miniaturized 16S rRNA Amplicon Sequencing with the Labcyte Echo® 52...DOWNLOAD

G123

Miniaturized 16S rRNA Amplicon Sequencing with the Labcyte Echo® 52...

Jefferson Lai and John Lesnick

ABSTRACT

Our understanding of the microbial communities in human health, metagenomics, and metataxonomics has been growing rapidly in recent years and is being increasingl...

2017
PDF | 3.99 MB
Echo-Enhanced SMART-Seq® v4 for RNA SequencingDOWNLOAD

G122

Echo-Enhanced SMART-Seq® v4 for RNA Sequencing

Jefferson Lai, Anna Lehto, John Lesnick and Carl Jarman

ABSTRACT

As the cost of sequencing has continued to decline by orders of magnitude in the past ten years, scientists are enabled to ask deeper and more complex questions a...

2017
PDF | 3.05 MB
A Method to Streamline and Miniaturize Nextera™ Library Preparation...DOWNLOAD

G118

A Method to Streamline and Miniaturize Nextera™ Library Preparation...

John Lesnick

ABSTRACT

The ongoing evolution of next-generation sequencing (NGS) technologies has reduced sequencing costs by orders of magnitude and significantly increased throughput....

2017
PDF | 750.91 KB
High-throughput Miniaturization of Cytochrome P450 Time-dependent I...DOWNLOAD

D101

High-throughput Miniaturization of Cytochrome P450 Time-dependent I...

Jing Wang

ABSTRACT

Early assessment of the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) properties of drug candidates has become a critical part of modern dr...

2017
PDF | 265.90 KB
Miniaturization of Cytochrome P450 Time-dependent Inhibition Screen...DOWNLOAD

D102

Miniaturization of Cytochrome P450 Time-dependent Inhibition Screen...

Jing Wang

ABSTRACT

Early assessment of the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) properties of drug candidates has become a critical part of modern dr...

2017
PDF | 263.68 KB
Miniaturization of Multiple Displacement Amplification (MDA) of Gen...DOWNLOAD

G106

Miniaturization of Multiple Displacement Amplification (MDA) of Gen...

Labcyte

ABSTRACT

Advances in whole-genome amplification have enabled sequencing of DNA and RNA from a single cell, or what is commonly called Single-cell Genomics (SCG). SCG has b...

2017
PDF | 281.42 KB
The reliability of assay-ready plates for cell-based screening enab...DOWNLOAD

CUSTOMER APP NOTE

The reliability of assay-ready plates for cell-based screening enab...

Sheraz Gul and Markus Wolf

ABSTRACT

In a collaboration between the Fraunhofer Institute for Molecular Biology and Applied Ecology (Hamburg, Germany),
and the National University of Ireland (NU...

2017
PDF | 1.01 MB
Preparation of Mouse Plasma Microsamples for LC-MS/MS Analysis Usin...DOWNLOAD

D111

Preparation of Mouse Plasma Microsamples for LC-MS/MS Analysis Usin...

Randy Dyer

ABSTRACT

Serial microsampling of animals reduces the overall number of animals sampled and euthanized for toxicology studies. Traditional composite studies in mice can req...

2017
PDF | 287.25 KB
Effective Miniaturization of Illumina Nextera XT Library Prep for M...DOWNLOAD

G121

Effective Miniaturization of Illumina Nextera XT Library Prep for M...

Jefferson Lai, John Lesnick, Noël Ruppert

ABSTRACT

The cost of sequencing per nucleotide has been declining by orders of magnitude over the past ten years; however library preparation of samples for next-generatio...

2017
PDF | 965.62 KB
High-Precision Cell Dispensing with the Labcyte Echo® Liquid HandlerDOWNLOAD

D107

High-Precision Cell Dispensing with the Labcyte Echo® Liquid Handler

John Lesnick, Aurore Lejeune-Dodge, Noël Ruppert, Carl Jarman

ABSTRACT

In this technical note, we demonstrate the utility of the Labcyte Echo Liquid Handler to accurately dispense a variety of cell lines to ensure uniformity and viab...

2016
PDF | 1.26 MB
Miniaturized PIK3CA Mutational Analysis Utilizing the Labcyte Echo®...DOWNLOAD

G115

Miniaturized PIK3CA Mutational Analysis Utilizing the Labcyte Echo®...

John Lesnick, Linda Orren, Noël Ruppert

ABSTRACT

By combining the acoustic liquid transfer of the Labcyte Echo Liquid Handler with real-time PCR mutation analysis, we have demonstrated a highly efficient, low-co...

2016
PDF | 1.54 MB