APPLICATION NOTES

POD™ Automation Platform Application Highlight High‐Throughput Dose...

Labcyte scientists

ABSTRACT

The POD™ automation platform utilizes the revolutionary Echo® liquid handler and the Echo® Dose Response software application to instantly produce higher quality...

2010
PDF | 644.80 KB
Miniaturized Quantitative PCR in 1536-Well Plate Format Using the E...DOWNLOAD

G101

Miniaturized Quantitative PCR in 1536-Well Plate Format Using the E...

C Glazer, S Datwani

ABSTRACT

Miniaturizing quantitative PCR (qPCR) reactions into 1536-well plates holds great promise for increased throughput and reagent savings. However, delivering reagen...

2010
PDF | 228.86 KB
Keeping DMSO Concentration Below 0.5% to Minimize its Effect in HTS...

Gallagher A, Koechlein D, Shieh J

ABSTRACT

Dimethyl sulfoxide (DMSO) is a commonly used solvent for compounds. DMSO accelerates protein unfolding and weakens the binding between small molecules and protein...

2007
PDF | 152.34 KB
MicroClime Environmental Lids Reduce Edge Effects in Multi-Well Plates

Labcyte scientists

ABSTRACT

Edge effects—the tendency of the contents of wells in the outer rows and columns of a multi-well microplate to vary from wells in the interior of the plate—are du...

2006
PDF | 2.12 MB
Optimizing Heat Sealing of Labcyte® Echo™ Qualified COC Source Plat...

Labcyte scientists

ABSTRACT

Cyclic olefin copolymer (COC) is a stiff material of high melting point. Microplates made of COC can be effectively heat-sealed with a laminated seal on a Velocit...

2006
PDF | 21.55 KB
Miniaturized Luminescent Metabolism Profiling Assays

Shieh J, Worzella T, Gallagher A

ABSTRACT

Cytochrome P450 (CYP) and monoamine oxidases (MAO) are two groups of enzymes that metabolize drugs. The interactions of these enzymes and compounds are studied ca...

2006
PDF | 396.54 KB
Bioluminescence for Drug Metabolism Profiling

Worzella T, Cali J, Cosby N, Shieh J, Gallagher A, Zerzaschnitzhofer G, Titus K

ABSTRACT

This article describes metabolic profiling applications in which compounds are assayed against several different drug metabolizing enzymes on the same assay plate...

2006
PDF | 162.47 KB