APPLICATION NOTES

* Requires registration

Echo Application Highlight Protein Crystallography

Labcyte

ABSTRACT

The Echo liquid handler enables protein crystal formation with sitting drop volumes as little as 50 nL. Nanoliter volumes of protein and crystallography reagents...

2012
PDF | 224.71 KB
Miniaturized Gene Expression in as Little as 250 nL

Labcyte

ABSTRACT

2011
PDF | 1.50 MB
POD™ Automation Platform Application Highlight High‐Throughput Dose‐Response

Labcyte scientists

ABSTRACT

The POD™ automation platform utilizes the revolutionary Echo® liquid handler and the Echo® Dose Response software application to instantly produce higher quality...

2010
PDF | 644.80 KB
Miniaturized Quantitative PCR in 1536-Well Plate Format Using the Echo® Liquid HandlerVIEW

G101

Miniaturized Quantitative PCR in 1536-Well Plate Format Using the Echo® Liquid Handler

C Glazer, S Datwani

ABSTRACT

Miniaturizing quantitative PCR (qPCR) reactions into 1536-well plates holds great promise for increased throughput and reagent savings. However, delivering reagen...

2010
PDF | 228.86 KB
Keeping DMSO Concentration Below 0.5% to Minimize its Effect in HTS Assays

Gallagher A, Koechlein D, Shieh J

ABSTRACT

Dimethyl sulfoxide (DMSO) is a commonly used solvent for compounds. DMSO accelerates protein unfolding and weakens the binding between small molecules and protein...

2007
PDF | 152.34 KB
MicroClime Environmental Lids Reduce Edge Effects in Multi-Well Plates

Labcyte scientists

ABSTRACT

Edge effects—the tendency of the contents of wells in the outer rows and columns of a multi-well microplate to vary from wells in the interior of the plate—are du...

2006
PDF | 2.12 MB
Optimizing Heat Sealing of Labcyte® Echo™ Qualified COC Source Plates with the Velocity11 PlateLoc®

Labcyte scientists

ABSTRACT

Cyclic olefin copolymer (COC) is a stiff material of high melting point. Microplates made of COC can be effectively heat-sealed with a laminated seal on a Velocit...

2006
PDF | 21.55 KB
Miniaturized Luminescent Metabolism Profiling Assays

Shieh J, Worzella T, Gallagher A

ABSTRACT

Cytochrome P450 (CYP) and monoamine oxidases (MAO) are two groups of enzymes that metabolize drugs. The interactions of these enzymes and compounds are studied ca...

2006
PDF | 396.54 KB
Bioluminescence for Drug Metabolism Profiling

Worzella T, Cali J, Cosby N, Shieh J, Gallagher A, Zerzaschnitzhofer G, Titus K

ABSTRACT

This article describes metabolic profiling applications in which compounds are assayed against several different drug metabolizing enzymes on the same assay plate...

2006
PDF | 162.47 KB