POSTERS AND PRESENTATIONS

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Miniaturization and Optimization of a Two-Plasmid Expression Pathway in myTXTL® Cell-Free Protein Expression Kit (Arbor Biosciences) Using Labcyte...

Evelyn Eggenstein, et. al.

ABSTRACT

In vitro transcription (TX)-translation (TL) is a rapidly developing technology with vast potential for synthetic biology and bio-engineering. myTXTL®, an E. coli based cell-free protein expression...

2018
PDF | 1.14 MB
High-Throughput Microliter-Sized Cell-Free Transcription-Translation Reactions for Synthetic Biology Applications Using the Echo® 550 Liquid Handler

Ryan Marshall, et. al.

ABSTRACT

Cell-free transcription-translation (TXTL) systems have become powerful tools to help understand complex biochemical systems by executing DNA programs in test tube reactions. These systems have rec...

2018
PDF | 998.55 KB
Miniaturization of a Five Piece PIK3CA Plasmid Assembly by Utilizing NEBuilder® HiFi DNA Assembly Cloning Kit and the Labcyte Echo® 525 Liquid Handler

Jared Bailey et al.

ABSTRACT

Synthetic biology is an interdisciplinary science with the potential to impact several academic and industrial applications including the creation of novel therapeutics and vaccines, plant science...

2018
PDF | 2.04 MB
Efficient Plasmid Validation By Multiplexing and Miniaturizing Illumina Nextera XT with the Echo® 525 Acoustic Liquid Handler

John Lesnick et al.

ABSTRACT

Synthetic biology is an interdisciplinary science with the potential to impact several academic and industrial applications including the creation of novel therapeutics and vaccines, plant science...

2018
PDF | 1.58 MB
Acoustic Mist Ionization of Organic Fluids for High Throughput Mass Spectrometry

Deepshika Angrish, et al.

SLAS2018

ABSTRACT

We present the development of direct acoustic mist ionization (AMI) mass spectrometry to deliver label-free, high-throughput screening (HTS) platform1. We use a customized Labcyte Echo acoustic liq...

2018
PDF | 1.09 MB
Echo-Miniaturized SMART-Seq v4 for RNASeq Applications

Jefferson Lai, et al.

SLAS2018:

ABSTRACT

As the cost of sequencing has continued to decline by orders of magnitude in the past ten years, scientists are enabled to ask deeper and more complex questions about transcriptomics. Consequently,...

2018
PDF | 507.67 KB
Long-Term Compound Storage in Acoustically Enabled Tubes: Theory and Experiment

Carson T. Riche, et al.

SLAS2018

ABSTRACT

Acoustic transfer of compounds between microplates by Echo® liquid handling instruments has facilitated high-throughput drug discovery at a reduced cost. Until now, these workflows used Echo® quali...

2018
PDF | 408.91 KB
Sonoporation: A Novel Method for Mammalian Cell Transfection

Marsha N Blauwkamp PhD, et al.

SLAS2018

ABSTRACT

We present a novel transfection method called sonoporation, which introduces genetic material and proteins into mammalian cells using the acoustic excitation of microbubbles. Antibody-coated micro...

2018
PDF | 486.80 KB
Reduced Animal Usage and Decreased Study Cost through Microsampling Approaches During Preclinical Safety Testing

Rabia Khan, et al.

SLAS2018

ABSTRACT

Pharmacokinetic and pharmacodynamic safety testing relies heavily upon small animal models during the preclinical phase. Promising lead compounds are typically administered to an animal cohort and...

2018
PDF | 308.70 KB
Miniaturized 16S rRNA Amplicon Sequencing for Metagenomic and Microbiome Studies

Jefferson Lai, et al.

SLAS2018

ABSTRACT

Our understanding of the role of the human microbiome in health and disease has been growing rapidly in recent years and is being increasingly elucidated every day. Amplicon sequencing of highly co...

2018
PDF | 294.32 KB
Acoustic Droplet Ejection of Aqueous Solutions from an Acoustic Tube – Enabling qPCR

Carson T. Riche Ph.D, et al.

SLAS2018

ABSTRACT

Acoustic droplet ejection (ADE) is a fluid dispensing technology, whereby high-frequency sound waves are focused on the surface of a fluid to eject nano- and picoliter volumes with high accuracy an...

2018
PDF | 301.86 KB
A New Platform for High-Throughput Mass Spectrometry: Acoustic Droplet Ejection with an Open Port Probe Sampling Interface

Lucien Ghislain, et al.

SLAS2018

ABSTRACT

We demonstrate a system combining acoustic droplet ejection (ADE) with the open port probe sampling interface for high-throughput mass spectrometry (MS). We use a customized Labcyte Echo® acoustic...

2018
PDF | 1.47 MB