POSTERS AND PRESENTATIONS

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Assembly of Measurement Standards for Metagenomic Analyses by Labcyte Echo 525

J. R. Carmical, et. al.

ABSTRACT

We employed Labcyte’s Echo 525, a unique technology capable of delivering extremely precise nanoliter volumes through acoustic liquid transfer requiring no physical contact, thus eliminating the po...

2017
PDF | 914.22 KB
Utilizing the Labcyte Echo® Liquid Handler to Validate the Generation of Recombinant Cell Lines by Next-Generation Sequencing

John Lesnick

SLAS2017

ABSTRACT

Utilizing the Labcyte Echo 525 liquid handler we demonstrate an efficient and robust gene assembly method to generate a fusion protein for functional cellular assays. A PTEN-GFP construct was gener...

2017
PDF | 1.03 MB
Effective Miniaturization of Small Whole Genome Next-Generation Sequencing by Utilizing Illumina Nextera XT Library Preparation and the Labcyte Ech...

Jefferson Lai

SLAS2017

ABSTRACT

The cost of sequencing per nucleotide has been declining by orders of magnitude in the past ten years, due to continuous improvement in next-generation sequencing technologies. However, library pre...

2017
PDF | 1.56 MB
A Method to Streamline and Miniaturize Nextera Library Preparation for Illumina Next-Gen Sequencing Using the Labcyte Echo® 525 Liquid Handler

John Lesnick

SLAS2017

ABSTRACT

The advances made in next-generation sequencing technology, in both large-scale DNA sequencing chemistries and instrumentation, have increased the speed and decreased the cost of sequencing per nuc...

2017
PDF | 805.76 KB
Investigation of micro blood sampling from the marginal ear vein of the Göttingen mini-pig for non-clinical safety studies

H. A. Blunt, S.P. Hackford, M.P. Blackwell

ABSTRACT

Over recent years, the use of the mini-pig for non-clinical toxicology studies has expanded, leading to the species becoming a viable non-rodent alternative, accepted by regulatory authorities.

2016
PDF | 380.71 KB
Reduce Animal Usage in Pharmacokinetic and Pharmacodynamic Studies

Labcyte

ABSTRACT

Infographic showing the advantages of serial sampling enabled by microsampling using the Echo Liquid Handler.

2016
PDF | 1.73 MB
Optimising cell line generation with acoustic dispensing technology

Anna-Lina Cavallo , Silvio Di Castro

ABSTRACT

Plasmid-based CRISPR libraries (RNA-guided CRISPR/Cas9 system, one of several precise genome editing techniques available) offer a reliable and relatively inexpensive option for fast identification...

2016
PDF | 209.04 KB
PIK3CA Mutational Analysis Utilizing the Labcyte Echo® Liquid Handler to Reduce Sample Amount, Reduce Cost, and Increase Throughput to Broadly Asse...

Randy Dyer, et al.

SLAS2016

ABSTRACT

The phosphoinositide-3 kinase (PI3K)/AKT signaling network is one of the two most commonly mutated pathways identified in human cancers and the most frequently mutated pathway in breast cancer. Som...

2016
PDF | 2.46 MB
Establishing a Method for High Precision Cell Dispensing with the Echo® 500 Series of Liquid Handlers

Carl Jarman, et al.

SLAS2016

ABSTRACT

Cell-based assays have become indispensable for both industry and academic research efforts. Cell-based assays are put to use in various applications across the drug discovery and development traje...

2016
PDF | 922.52 KB
Utilization of the Labcyte MicroClime® Lid to Reduce the Edge Effects in a Cell-Based Proliferation Assay

Randall Lowe, et al.

SLAS2016

ABSTRACT

Cell-based assays have become an essential tool for both academia and industry-based research for a wide variety of applications. These assays allow researchers to analyze complex cellular function...

2016
PDF | 658.39 KB
Evaluation of Combination Treatment Efficacy of PI3K Inhibitors Utilizing the Labcyte Echo® Liquid Handler and Echo® Combination Screen Software in...

Linda Orren, et al.

SLAS2016

ABSTRACT

Class I Phosphoinositide 3-kinase (PI3K) proteins have been extensively characterized with respect to their roles in cell proliferation and tumorigenesis, and therefore serve as desirable targets f...

2016
PDF | 2.17 MB
Detection of Phospho-Akt (Ser 473) as an Indication of PI3K Pathway Activation in MCF7 Cells Using the Labcyte  Echo® Liquid Handler and Cisbio’s H...

Bonnie Edwards, et al.

SLAS2016

ABSTRACT

The Phosphoinositide 3-kinase (PI3K) pathway has been studied extensively for its role in the development of human cancers.  Tools to detect the regulatory impact of PI3K inhibitors on pathway acti...

2016
PDF | 2.27 MB