POSTERS AND PRESENTATIONS

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Evaluation of Combination Treatment Efficacy of PI3K Inhibitors Utilizing the Labcyte Echo® Liqui...

Linda Orren, et al.

SLAS2016

ABSTRACT

Class I Phosphoinositide 3-kinase (PI3K) proteins have been extensively characterized with respect to their roles in cell proliferation and tumorigenesis, and therefore serve as desirable targets f...

2016
PDF | 2.17 MB
Detection of Phospho-Akt (Ser 473) as an Indication of PI3K Pathway Activation in MCF7 Cells Usin...

Bonnie Edwards, et al.

SLAS2016

ABSTRACT

The Phosphoinositide 3-kinase (PI3K) pathway has been studied extensively for its role in the development of human cancers.  Tools to detect the regulatory impact of PI3K inhibitors on pathway acti...

2016
PDF | 2.27 MB
Identification of PI3Ka Inhibitors with and Automated Echelon® Fluorescence Polarization Assay Us...

Linda Orren, et al.

SLAS2016

ABSTRACT

Phosphoinositide 3-kinase alpha (PI3Kα) is frequently implicated in human cancer because of its role in the induction of cell proliferation and survival and is highly sought after as a drug develop...

2016
PDF | 2.63 MB
Utilizing the Labcyte Echo® Liquid Handler and the BMG PHERAstar® FS to Miniaturize and Automate...

Austin Swafford Ph.D., et al.

SLAS2016

ABSTRACT

Epigenetic processes are attracting considerable attention in drug discovery as their fundamental roles in the regulation of normal cell development and contributions to disease states become more...

2016
PDF | 2.33 MB
Utilizing the Labcyte Echo® Liquid Handler and Gateway® Gene Assembly in the Generation and Tran...

John Lesnick, et al.

SLAS2016

ABSTRACT

The study of protein function relies upon recombinant gene assembly for protein expression and functional assays. This strategy is particularly important when available information regarding functi...

2016
PDF | 812.63 KB
Further Development of an Acoustic Source for High Throughput Label Free Mass Spectrometry Screening

Jonathan Wingfield, et al.

SLAS2016

ABSTRACT

At SLAS 2015 Washington we introduced the early development of a novel acoustic loading system for use with ambient ionization mass spectrometry. Our system is capable of loading 10,000 samples/hou...

2016
PDF | 500.67 KB
Seconds per Sample with Echo‐DART‐MS: Acoustic Loading of a Mass Spectrometer for High‐Throughput...

E. Hall, et al.

SLAS2016

ABSTRACT

Commercial mass spectrometry (MS) instruments offer label‐free analytical detection at a throughput of ~ 10 seconds per sample. Here we use the fast and precise sample ejection capabilities of the...

2016
PDF | 338.16 KB
Transferring nano- to milliliters of aqueous fluids with sound: the science behind the new Labcyt...

EK Sackmann, et. al.

ABSTRACT

Acoustic liquid handling utilizes high-frequency sound waves that are focused on the surface of a fluid to eject nanoliter-scale droplets with high accuracy and precision. The Echo® 525 liquid hand...

2015
PDF | 1.65 MB
The Advantages of Acoustic Liquid Handling for Drug Sensitivity Screening

C Jarman, K Wennerberg, B Yadav, T Pemovska, T Aittokallio, B Edwards

ABSTRACT

Recently identified associations between variants of cancer genes and drug resistance have increased the value for comprehensive drug sensitivity screening in combination with molecular profiling o...

2013
PDF | 626.37 KB
Next Generation Sequencing Sample Preparation Utilizing the Echo Liquid Handler

Lee H, Lee D, Chan K

ABSTRACT

The advent of Next-generation sequencing (NGS) has enabled researchers to overcome the limitations in resolution, scalability, and throughput experienced with capillary electrophoresis-based Sanger...

2013
PDF | 1.17 MB
Walk Away, Nanoscale Assay Preparation for High Throughput PCR Using the Access™ Laboratory Works...

C Glazer, R Cutting, T Allison, R Dyer, B Nelson, J Barco, S Datwani, M Sonntag

ABSTRACT

2012
PDF | 1.18 MB
Nanoliter Scale High Throughput Protein Crystallography Screening

B Edwards, D Harris, S Datwani, B Eaton, R Huang, J Barco

ABSTRACT

Small scale protein crystallography offers tremendous advantages in screening conditions against small quantities of protein. A drawback of traditional liquid handling capabilities is reproducibili...

2012
PDF | 415.85 KB