POSTERS AND PRESENTATIONS

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Optimising cell line generation with acoustic dispensing technology

Anna-Lina Cavallo , Silvio Di Castro

ABSTRACT

Plasmid-based CRISPR libraries (RNA-guided CRISPR/Cas9 system, one of several precise genome editing techniques available) offer a reliable and relatively inexpensive option for fast identification...

2016
PDF | 209.04 KB
PIK3CA Mutational Analysis Utilizing the Labcyte Echo® Liquid Handler to Reduce Sample Amount, Reduce Cost, and Increase Throughput to Broadly Asse...

Randy Dyer, et al.

SLAS2016

ABSTRACT

The phosphoinositide-3 kinase (PI3K)/AKT signaling network is one of the two most commonly mutated pathways identified in human cancers and the most frequently mutated pathway in breast cancer. Som...

2016
PDF | 2.46 MB
Establishing a Method for High Precision Cell Dispensing with the Echo® 500 Series of Liquid Handlers

Carl Jarman, et al.

SLAS2016

ABSTRACT

Cell-based assays have become indispensable for both industry and academic research efforts. Cell-based assays are put to use in various applications across the drug discovery and development traje...

2016
PDF | 922.52 KB
Utilization of the Labcyte MicroClime® Lid to Reduce the Edge Effects in a Cell-Based Proliferation Assay

Randall Lowe, et al.

SLAS2016

ABSTRACT

Cell-based assays have become an essential tool for both academia and industry-based research for a wide variety of applications. These assays allow researchers to analyze complex cellular function...

2016
PDF | 658.39 KB
Evaluation of Combination Treatment Efficacy of PI3K Inhibitors Utilizing the Labcyte Echo® Liquid Handler and Echo® Combination Screen Software in...

Linda Orren, et al.

SLAS2016

ABSTRACT

Class I Phosphoinositide 3-kinase (PI3K) proteins have been extensively characterized with respect to their roles in cell proliferation and tumorigenesis, and therefore serve as desirable targets f...

2016
PDF | 2.17 MB
Detection of Phospho-Akt (Ser 473) as an Indication of PI3K Pathway Activation in MCF7 Cells Using the Labcyte  Echo® Liquid Handler and Cisbio’s H...

Bonnie Edwards, et al.

SLAS2016

ABSTRACT

The Phosphoinositide 3-kinase (PI3K) pathway has been studied extensively for its role in the development of human cancers.  Tools to detect the regulatory impact of PI3K inhibitors on pathway acti...

2016
PDF | 2.27 MB
Identification of PI3Ka Inhibitors with and Automated Echelon® Fluorescence Polarization Assay Using the Labcyte Access Workstation

Linda Orren, et al.

SLAS2016

ABSTRACT

Phosphoinositide 3-kinase alpha (PI3Kα) is frequently implicated in human cancer because of its role in the induction of cell proliferation and survival and is highly sought after as a drug develop...

2016
PDF | 2.63 MB
Utilizing the Labcyte Echo® Liquid Handler and the BMG PHERAstar® FS to Miniaturize and Automate a Series of G9a Histone Methyltransferase Assays

Austin Swafford Ph.D., et al.

SLAS2016

ABSTRACT

Epigenetic processes are attracting considerable attention in drug discovery as their fundamental roles in the regulation of normal cell development and contributions to disease states become more...

2016
PDF | 2.33 MB
Utilizing the Labcyte Echo® Liquid Handler and Gateway® Gene Assembly in the Generation and Transfection of a PTEN-GFP Construct into a PTEN Null...

John Lesnick, et al.

SLAS2016

ABSTRACT

The study of protein function relies upon recombinant gene assembly for protein expression and functional assays. This strategy is particularly important when available information regarding functi...

2016
PDF | 812.63 KB
Further Development of an Acoustic Source for High Throughput Label Free Mass Spectrometry Screening

Jonathan Wingfield, et al.

SLAS2016

ABSTRACT

At SLAS 2015 Washington we introduced the early development of a novel acoustic loading system for use with ambient ionization mass spectrometry. Our system is capable of loading 10,000 samples/hou...

2016
PDF | 500.67 KB
Seconds per Sample with Echo‐DART‐MS: Acoustic Loading of a Mass Spectrometer for High‐Throughput Screening

E. Hall, et al.

SLAS2016

ABSTRACT

Commercial mass spectrometry (MS) instruments offer label‐free analytical detection at a throughput of ~ 10 seconds per sample. Here we use the fast and precise sample ejection capabilities of the...

2016
PDF | 338.16 KB
Transferring nano- to milliliters of aqueous fluids with sound: the science behind the new Labcyte Echo® Qualified Reservoir

EK Sackmann, et. al.

ABSTRACT

Acoustic liquid handling utilizes high-frequency sound waves that are focused on the surface of a fluid to eject nanoliter-scale droplets with high accuracy and precision. The Echo® 525 liquid hand...

2015
PDF | 1.65 MB