POSTERS AND PRESENTATIONS

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Identification of PI3Ka Inhibitors with and Automated Echelon® Fluorescence Polarization Assay Using the Labcyte Access Workstation

Linda Orren, et al.

SLAS2016

ABSTRACT

Phosphoinositide 3-kinase alpha (PI3Kα) is frequently implicated in human cancer because of its role in the induction of cell proliferation and survival and is highly sought after as a drug develop...

2016
PDF | 2.63 MB
Utilizing the Labcyte Echo® Liquid Handler and the BMG PHERAstar® FS to Miniaturize and Automate a Series of G9a Histone Methyltransferase Assays

Austin Swafford Ph.D., et al.

SLAS2016

ABSTRACT

Epigenetic processes are attracting considerable attention in drug discovery as their fundamental roles in the regulation of normal cell development and contributions to disease states become more...

2016
PDF | 2.33 MB
Utilizing the Labcyte Echo® Liquid Handler and Gateway® Gene Assembly in the Generation and Transfection of a PTEN-GFP Construct into a PTEN Null...

John Lesnick, et al.

SLAS2016

ABSTRACT

The study of protein function relies upon recombinant gene assembly for protein expression and functional assays. This strategy is particularly important when available information regarding functi...

2016
PDF | 812.63 KB
Transferring nano- to milliliters of aqueous fluids with sound: the science behind the new Labcyte Echo® Qualified Reservoir

EK Sackmann, et. al.

ABSTRACT

Acoustic liquid handling utilizes high-frequency sound waves that are focused on the surface of a fluid to eject nanoliter-scale droplets with high accuracy and precision. The Echo® 525 liquid hand...

2015
PDF | 1.65 MB
The Advantages of Acoustic Liquid Handling for Drug Sensitivity Screening

C Jarman, K Wennerberg, B Yadav, T Pemovska, T Aittokallio, B Edwards

ABSTRACT

Recently identified associations between variants of cancer genes and drug resistance have increased the value for comprehensive drug sensitivity screening in combination with molecular profiling o...

2013
PDF | 626.37 KB
Next Generation Sequencing Sample Preparation Utilizing the Echo Liquid Handler

Lee H, Lee D, Chan K

ABSTRACT

The advent of Next-generation sequencing (NGS) has enabled researchers to overcome the limitations in resolution, scalability, and throughput experienced with capillary electrophoresis-based Sanger...

2013
PDF | 1.17 MB
Walk Away, Nanoscale Assay Preparation for High Throughput PCR Using the Access™ Laboratory Workstation and the Roche LightCycler® 1536 System

C Glazer, R Cutting, T Allison, R Dyer, B Nelson, J Barco, S Datwani, M Sonntag

ABSTRACT

2012
PDF | 1.18 MB
Nanoliter Scale High Throughput Protein Crystallography Screening

B Edwards, D Harris, S Datwani, B Eaton, R Huang, J Barco

ABSTRACT

Small scale protein crystallography offers tremendous advantages in screening conditions against small quantities of protein. A drawback of traditional liquid handling capabilities is reproducibili...

2012
PDF | 415.85 KB
A Miniaturized and Automated P450-Glo™ Screening System Using the Echo® Liquid Handler (with Promega Corp.)

J Wang, J Barco, T Worzella, K Kershner

ABSTRACT

Early assessment of cytochrome P450 (CYP) inhibition has become an essential component of drug discovery screening. The CYP3A4 enzyme is the most abundant enzyme in the liver and plays a major rol...

2012
PDF | 489.42 KB
Miniaturized GloSensor™ cAMP Assay Using the Echo® Liquid Handler (with Promega Corp.)

T Worzella, T Allison, P Stecha, K Kershner, M Cong, C Zimprich, C Cowan

ABSTRACT

As biological assays used for HTS and uHTS are miniaturized, it is critical to maintain assay sensitivity while minimizing reagent volumes and maximizing throughput. The GloSensor™ cAMP Assay provi...

2012
PDF | 1.17 MB
Validation of Low Volume 1536 “Assay Ready” Compound Plates for a Nuclear Hormone Receptor Screen

H Eriksson, J Brengdahl, A Hogner, B Becker

ABSTRACT

The predispensing of compound libraries by acoustic droplet ejection is a convenient way of preparing ”assay ready” compound plates. This method also allows for the direct (i.e. no predilution nece...

2011
PDF | 372.54 KB
Miniaturized Genotyping Reactions with the Echo® Liquid Handler

C Glazer, T Allison, R Dyer, J Barco, S Datwani

ABSTRACT

Advanced in miniaturization of genotyping assays have tremendously improved reaction throughput, but not without challenges. Efforts to reduce reagent costs and decrease sample volume requirements...

2011
PDF | 1.21 MB